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The FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, contraindicating use in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

More significant structural changes, such as improved firmness and smoother texture, typically become visible after two to three months of consistent nightly use

Most were mild or moderate

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In-use travel scenarios: A reconstituted vial or pen that you take out of the fridge for a 15-minute injection is fine