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Muscle tissue is metabolically active and contributes to heat production, so maintaining muscle mass can help mitigate cold sensitivity

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Here is a helpful visual, originally from the Textbook of Functional Medicine : Enter this visual, or similar: What is so striking to me about this visual is how incredibly important nutrition is for both phases

are highly exposed to environmental pollutants

Upon oxidative mitochondrial damage, a greater number of MDVs are targeted to lysosomes for degradation, which in turn blocks the secretion of mitochondrial content by EVs (Todkar et al., 2021)