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Safety, Side Effects and Contraindications All three options are described as generally well tolerated

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222 In one randomized placebo-controlled trial, 120 nondiabetic men and women aged 1870 years with stage 34 CKD and low ( 50 year) outcomes after kidney donation compared to well-matched healthy controls

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The inability to appropriately sense, buffer, or correct proteotoxic stress results in the accumulation of misfolded proteins, organelle dysfunction, aberrant signaling, and ultimately tissue failure