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These agents mimic the biological action of the native incretin hormone GLP-1 but are structurally modified to resist degradation by the enzyme dipeptidyl peptidase 4 (DPP-4), thereby extending their half-life and duration of action (Zheng et al., 2024

Because retatrutide already contains three receptor activities, combining it with an amylin analogue is a research hypothesis without supporting evidence, and nothing here should be read as a suggestion to combine them

doi: 10.1038/s41598-017-15122-0 251 WangF.XieY.LY.WangY.ZhangZ.XiF.et al