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Genetic studies have revealed that IL1B polymorphisms are associated with increased PD risk, suggesting that individual variability in both TNF- and IL-1 may influence disease susceptibility and early onset [184, 189, 195]

doi:10.1016/S0092-8674(00)81883-8 57

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In this article, we will explore some of the various theories that are currently in circulation, which outline the cause as: Excessive production of porphyrin by skin bacteria stimulated by B12 A cobalt allergy Relative deficiency of vitamin B12 cofactors A detoxification reaction Vitamin B12 Acne The Work of Skin Bacteria