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This maintains the natural pulsatile pattern that the hypothalamic-pituitary axis expects, reducing the risk of desensitization
For instance, taking GLP-1 drugs alongside other medications that slow gastric emptying (such as some pain medications) could increase the risk of side effects
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In other words, Cagrilintide is often treated as a second-step optimisation peptide , layered on top of a GLP-1 foundation rather than replacing it
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