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In parallel, yolk sac-like tissues from iPSCs were used to generate mesodermal derivatives resembling early extraembryonic hemato-vascular lineages, including CD31+ endothelial cells and CD45+ hematopoietic progenitors, which further differentiated into microglia and pericyte-like cells
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The authors of this study explain the upregulation with the increased availability of Sec, although this was not shown for knockout of other selenoproteins, e.g., GPX1 [107]
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