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Inhibiting RHOA signaling in mice increases glucose tolerance and numbers of enteroendocrine and other secretory cells in the intestine
Deficiency is rare in dogs and usually corresponds with inherited dilated cardiomyopathy
Diabetes Care, 46(4), 801810
What this means for dosing calculations: the clinical trial protocols use fixed escalation schedules with specific dose targets (typically 8mg or 12mg maintenance)
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