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Open 6 , e235626 (2023)

This is particularly important for tendon and ligament injuries , where blood supply is naturally limited and healing times are prolonged

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Long-Acting GHRH Analog : Unlike natural GHRH, which has a short duration of action, CJC-1295 has been modified to bind to a receptor in the pituitary gland and stimulate growth hormone release continuously

154 The relatively low mechanical stress (about 45 Pa) derived by the ECM can stimulate the stem cell signaling pathway via the cytoskeleton/AIRE axis by activating the integrin beta 1/3 receptor, while excessive mechanical stress (~450 Pa) induces quiescence in BCSCs dependent on DDR2/STAT1/P27 signaling, which may explain conflicting results observed in previous individual studies