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Combining AOD-9604 and 5-Amino-1MQ creates synergy through complementary metabolic pathways: AOD-9604 stimulates lipolysis via beta-3 adrenergic receptors to mobilise stored triglycerides, while 5-Amino-1MQ inhibits NNMT enzyme activity to restore NAD+ availability and mitochondrial oxidative capacity
J Med Chem
In the knockout mice, there was no significant decrease in body weight or lipolysis, thus indicating the importance of the beta-adrenergic pathways in weight loss
Furthermore, it also prevents nutrients from being fully utilized in the body by altering their transport, storage, and excretion
It also keeps our nervous system healthy by making myelin
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