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Gene expression analyses were performed on peripheral blood rather than on specific target tissues such as the liver, kidney, stomach, or testes, and therefore may not fully reflect tissue-level molecular responses
reported that apoptotic extracellular vesicles released from residual liver tissue after PHx are cleared by circulating neutrophils, which increase the levels of progrowth factors such as HGF and FGF2 instead of proinflammatory cytokines to support regeneration in the liver remnant
Moreover, the expression levels of hyphal formation-related genes, including HWP1 , ECE1 , and ALS3 (Fig
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When these functions break down in advanced CKD, multiple biochemical disturbances may develop
