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These tools help detect potential safety signals but do not account for confounding variables such as baseline patient characteristics, comorbidities, or concomitant medication use
Critical revision: MJP, HK, MGK, KK
"Any patients with a history of peripheral arterial disease or any kind of vascular disease should discuss that with their doctor," Dr
Lancet Neurology 1, 173181
Blood Sugar Effects Both medications improve glucose metabolism: Liraglutide: HbA1c reduction of 0.5-1.0% at weight loss doses Originally developed for diabetes (Victoza) Modest glucose benefits at Saxenda doses Semaglutide: HbA1c reduction of 1.0-1.8% at diabetes doses Greater glucose improvement than liraglutide Significant benefit for prediabetes and diabetes For patients with diabetes or prediabetes, semaglutide provides greater metabolic benefit
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