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Numerically fewer patients reported adverse events such as gynecomastia or agitation, though the differences failed to reach statistical significance, likely in part due to small sample size
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Flexible Enzyme Works With Complex Drug Molecules "We were surprised by how flexible the enzyme turned out to be," said Jake Pedigo, lead author of the paper and a graduate student in the Bandarian lab
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High levels of cytoplasmic tyramine result in its transport into vesicles via VMAT2, displacing stored vesicular norepinephrine into the neuronal cytoplasm, resulting in an increase of cytoplasmic norepinephrine (Raiteri and Levi, 1986
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