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This is one reason head-to-head binding assays dont always match head-to-head secretion experiments and why researchers occasionally get surprised when GHRP-6 outperforms GHRP-2 in certain model contexts despite lower receptor binding affinity on paper

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(2010) 299:C189202

The spermatogenesis microenvironment reveals major anomalies with age, such as reduced number, organelle aging, aberrant hormone production, and deficiencies of the bloodtesticular barrier 4