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Gut microbial dysbiosis alters regulatory T cells (Tregs) and cytokine balance, perpetuating inflammatory pathways even in the absence of overt infection

The mean change in the WOMAC pain score at week 68 was 41.7 points with semaglutide and 27.5 points with placebo

We previously reported that MSCs is resistant to most of the chemotherapeutics but sensitive to micro-tubule targeting agents like paclitaxel and vincristine [94]

Clinical trials report gastrointestinal adverse events in 25-40% of participants, with severity often declining after 4-8 weeks of continued use