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While clinical trials show patients losing between 15% and 22% of their body weight on these medications, the most meaningful results are often the "non-scale victories," like having the stamina to play with your children or feeling comfortable in your favorite clothes again
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The present study was also supported by funds from the AMED-CREST from the Japan Agency for Medical Research and Development, AMED and research funds from the Yamagata prefectural government and the City of Tsuruoka
Therefore, a decrease in Cu transport in the brain could lead to an increase in oxidative stress as a consequence of increased release of ions that contribute to the formation of free radicals, a decrease in endogenous antioxidant systems (CU/Zn-SOD), and an increase in iron accumulation by decreasing the ferroxidase activity of ceruloplasmin [344]
That doesn't make compounded GLP-1 medications categorically unsafe
