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Patients typically have a BMI of 27 or higher, or a BMI of 25+ with weight-related health concerns such as elevated blood pressure, prediabetes, or sleep disruption
"Metabolism of leukotrienes by L-gamma-glutamyl-transpeptidase and dipeptidase from human polymorphonuclear granulocytes"
A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide
Level 3 evidence is assigned to case control studies or systematic reviews of case-control studies
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