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And in one of the studies, 16 of the 45 participants dropped out before the study ended

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Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes Diana Trofimovitch 1 , Steven J Baumrucker 2 Curr Pain Headache Rep 2020 Aug 26;24(10):64