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In the presence of O 2 , the catalyst Ru(II)-OH is regenerated

It is worth noting that febuxostat inhibits ABCG2 more strongly than the two known ABCG2 inhibitors (Ko143 and elacrida), which means that febuxostat has not only advantages over these two inhibitors but also stronger in safety and ability than other ABCG2 inhibitor ( Xanthine Oxidase Inhibitors Allopurinol Allopurinol, a xanthine oxidase inhibitor, is one of first-line drugs for the management of gout (Stamp et al., 2016