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One study found that Prx3 (mitochondrial Prx) is highly oxidized in the cartilage of elderly patients with osteoarthritis, indicating that oxidative stress is intensified in degenerative cartilage

Geier DA, Geier MR

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Furthermore, it appears that a significant portion of Ca 2+ released from the synaptic ER is directly transported to mitochondria at the MAMs [62]