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Side Effects of Each Weight-Loss Injection Ozempic Side Effects Effective for blood sugar control and weight loss Common gastrointestinal issues (nausea, diarrhea, bloating) Risk of pancreatitis (rare but serious) Can cause gallbladder problems , such as gallstones Wegovy Side Effects Higher dose of Semaglutide leads to better weight loss results More pronounced nausea and vomiting in the first few weeks Increased risk of gallbladder disease and pancreatitis Can cause dehydration due to frequent diarrhea Mounjaro Side Effects Generally fewer side effects than Wegovy and Ozempic Dual-action mechanism leads to better appetite suppression Can still cause nausea, but usually less severe Mild risk of stomach discomfort and constipation Some reports of mild headaches in the initial weeks Which Weight-Loss Injection Has the Least Side Effects