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They found heightened AMPK activity in MDSCs from tumor-bearing mice and human ovarian cancer patients, driven by GM-CSF from cancer cells via STAT5-dependent transcription of the Ampk1 gene
The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content
This action stimulates adipogenesis by increasing the glycogen synthase kinase-3-mediated phosphorylation of -catenin, and by increasing adipocyte differentiation through upregulation of the adipogenic transcription factors CCAAT-enhancer binding protein alpha (C/EBP) and peroxisome proliferative-activated receptor gamma (PPAR) [128, 129]
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