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They compared people taking tirzepatide to dulaglutide, an older GLP-1 drug predating semaglutide

S2CID 16101442

This includes individuals with severe anxiety or other psychological disorders, thyroid dysfunction, cardiovascular disease, and those who are pregnant or breastfeeding

On the other hand, the risks of HHF (HR 0.93, 95% CI 0.831.04 with GLP-1RAs and HR 0.69, 95% CI 0.610.79 with SGLT2is) and composite kidney outcomes excluding macroalbuminuria (HR 0.92, 95% CI 0.801.06 with GLP-1RAs and HR 0.55, 95% CI 0.480.64 with SGLT2is) significantly reduced with SGLT2is only