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Taken together, these results suggest that CPP-CAND inhibited the FOXO4-p53 interaction in the nucleus, which enabled the extranuclear transport of p53 and selectively induced apoptosis in senescent cells

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Behavioral alterations from MPs exposure demonstrated clear dose-response and particle-specific patterns (Jiang et al., 2023) reported no alteration in neuropsychiatric symptoms at 12 weeks but observed clear effects after 24 weeks of exposure, supporting cumulative neurotoxicity

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The homogenates were ultracentrifuged at 435,400 g for 30 min at 4 C to collect clear whole tissue lysates