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Glucagon-like peptide-1 (GLP-1) agonist therapies are increasingly being used for type 2 diabetes and obesity, but evidence now shows they also reduce inflammation across multiple organs through mechanisms related and unrelated to weight-loss-driven metabolic improvements
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But the papers authors, including researchers at Case Western Reserve University and Nora Volkow, the director of the National Institute on Drug Abuse, cautioned that the link between GLP-1 drugs and prevention of overdose deaths is unclear and that more research is needed, including randomized controlled trials
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The combined application of systemic and topical analgesia, as well as the integration of patient-controlled analgesia with multimodal approaches, has attracted increasing attention in clinical settings
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