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The anticancer activity of the glutathione-Epothilone conjugate towards the HepG-2 was 1.9 and 1.45 M, at molar ratios 1:2 and 1:4 M/M, respectively, by 2.5 higher activity folds, compared to the Epothilone individually
The SELECT cardiovascular outcomes trial demonstrated that semaglutide reduced the risk of major adverse cardiovascular events (heart attack, stroke, or cardiovascular death) by 20% in patients with obesity and established cardiovascular disease
the specific escalation steps and intervals were defined by the trial protocol
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