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In the SURMOUNT-5 trial (comparing tirzepatide to semaglutide at weight-loss doses), more people discontinued semaglutide due to side effects (5.6%) than tirzepatide (2.7%)

Compounded alternatives can't match the rigorous FDA oversight and clinical trial database supporting branded versions

That means food moves more slowly and can build up in the colon

The thyroid safety considerations for Retatrutide relate specifically to its GLP-1 activity, the same mechanism present in all GLP-1 receptor agonists

Most companies have pushed back strongly on this theory and demand has remained strong over the last several quarters