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In the Phase 2 obesity trial, the most common adverse events were gastrointestinal and dose-related, mostly mild-to-moderate, and were partially mitigated by a lower (2 mg vs 4 mg) starting dose
First escalation (5 mg): weeks 5 through 8 The jump from 2.5 mg to 5 mg is where many researchers first encounter meaningful side effects
Heres what you might experience
Starting at a lower dose or extending the dose-escalation period can minimize peak symptom severity
The serotonin neurons in nucleus raphe dorsalis of adult rat: a light and electron microscope radioautographic study
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