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Last reviewed: May 29, 2026 Last updated: May 29, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Effective for Long-Term Weight Loss A trial published in Nature Medicine found that, on average, Semaglutide led to a 10.2% weight reduction after 208 weeks

But blood levels of B12 mean little, and theyll rise regardless of therapeutic effectiveness

But Wegovy may increase the risk of pancreatitis, gallbladder disease, severe gastrointestinal side effects that may lead to dehydration or kidney injury, increased heart rate, and suicidal thoughts or behaviors