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Half-life comparison: Retatrutide (~6 days) vs Tirzepatide (~5 days) vs Semaglutide (~7 days) Steady State: 4-5 Weeks Why steady state matters: Most drugs reach steady state after ~ 45 half-lives , which for retatrutide is about 45 weeks of weekly injections
It is a long-acting analogue of amylin, a natural hormone involved in appetite and energy regulation
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