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En modelos animales preclnicos, dado su carcter de molcula pequea oral-activa, los diseos han contemplado dosificacin por va oral o intraperitoneal segn el protocolo aprobado por el comit de tica institucional, con esquemas de administracin diaria y ventanas de tratamiento que abarcan varias semanas para observar efectos sobre composicin corporal
Downstream observations in models include transcriptional changes consistent with enhanced mitochondrial function and lipid utilization
Akkermansia muciniphila adheres to enterocytes and strengthens the integrity of the epithelial cell layer (in Eng)
To maintain compound integrity, it should be stored in a cool, dry location away from light
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