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We found that PPARa over-expression significantly up-regulated FSP1 expression in neuron after TSCI, thus promoted the expression of CoQ10 and content of NADH, while icFSP1 inhibited this phenomenon, suggesting that FSP1 is a key effector of PPARa mediated lipid peroxidation related neuronal ferroptosis protection
At first glance, Dr Ashley Froese and Dr Dean Jones look fairly similar because both land at roughly two-thirds supported or partially supported. But that top-line similarity hides an important difference: Ashley is more explicit about experimental status and more disciplined about separating preclinical evidence from human evidence, while Dean more often presents a real mechanistic core with more certainty than the clinical evidence can currently support
P., Aranha, M
I felt very comfortable and satisfied with consultation
Any switch should be clinician-directed
