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Although direct in vivo evidence for lichen mediated modulation of these pathways remains limited, similar regulatory effects on HIF-1 and TGF- signaling have been described for various natural secondary metabolites in non-lichen systems, providing mechanistic context

In addition, brain microglia-derived cytokines (IL-1, IL-6, IL-12, and TNF) become elevated and appear to facilitate disease progression [46]

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These fillers plump up areas of skin indentation to make them less noticeable