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The difference isnt dramatic, but rates of nausea and diarrhea are modestly higher with tirzepatide compared to semaglutide in clinical trials

Second, by reducing nausea, patients may be more likely to take semaglutide as prescribed, which can lead to better long-term weight loss

These agents bind directly to GLP-1 receptors on pancreatic beta cells, triggering a cascade of physiological responses that improve glycemic control in patients with type 2 diabetes mellitus

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