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L-Glutathione can protect critical biological components against reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals

The two supplements that have the greatest level of evidence for melasma pigment & skin lightening include glutathione & polypodium extract

1,2 By specifically binding to the key hormone GLP-1, it regulates blood glucose levels and lipid metabolism

This peptide was also associated with a reduction in coarse wrinkles, and mottled pigmentation