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However, a published expert review of the Phase 2 data in Expert Opinion on Investigational Drugs (2023) noted: "Heart rate was increased by up to 6.7 beats/min by retatrutide, which may be detrimental and offset some of the benefits of weight loss" particularly for patients with cardiovascular comorbidities
Improved Adherence: The sublingual route is convenient and comfortable, which can improve adherence to treatment
As happened initially with the tirzepatide suit, the FDA isnt going after any semaglutide compounders until the judge makes a call, leaving options available for now
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