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Researchers studying receptor desensitization also use paired GHRH/GHS protocols to compare downregulation kinetics against single-agent controls, since repeated stimulation of the GHRH receptor alone can blunt responsiveness over time in ways that combined signaling may partially offset

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Nature Communications (2025) 11

Few adults under age 50 report having taken these drugs to treat chronic conditions, but similar shares of 1829-year-olds (7%) and 3049-year-olds (6%) report having taken them for weight loss