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Introducing a fluorine atom at this position yielded Compound 68 , which demonstrated slightly improved inhibitory potency (IC 50 : 6.5 nM) and significantly enhanced metabolic stability (RLM t 1/2 : 105 min) (Figure 19)
Sarris J, Byrne G, Castle D, Bousman C, Oliver G, Cribb L, et al
111-112: p
By synthesizing recent evidence, this study seeks to clarify the current state of development, identify research gaps, and provide a comprehensive framework for future research and industrial implementation
CLA is not an acute stimulant its effects accumulate over weeks of consistent use
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