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If they overlap in your system, you get additive stimulation of those receptors, and the result is not better efficacy
Were now understanding that weight loss is much more complicated than calories ingested as food and calories burned as exercise. Dietary composition, fiber content, food processing and refining, genetics and the individual microbiome (intestinal bacteria) are all factors that may play critical roles impacting metabolic efficiency and brain-driven eating patterns
This is arguably the most insidious risk of expired semaglutide
However, some GI side effects still occur and the adherence requirement (empty stomach, etc.) requires patient education
Touzot M et al
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