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138,139,140 These transport mechanisms, often coupled with vesicular trafficking and metabolic reprogramming, significantly reduce intracellular drug accumulation, attenuate target engagement and contribute to immune evasion, collectively undermining therapeutic efficacy
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It was first described in the scientific literature in 1993 by Sikiri and colleagues
As we learn more about GLP-1 RAs, we realize that they target many organ systems, including the pancreas, the stomach, brain, heart, kidneys, immune system (due to reduced inflammation), and skeletal muscle
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