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Although carnitine has been well tolerated, future studies are needed to evaluate the efficacy of prophylactic carnitine supplementation for the prevention of hepatotoxicity. 12 Some experimental and clinical data suggest that early intravenous supplementation with l-carnitine could improve survival in severe VPA-induced hepatotoxicity

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The core challenges are: limited blood supply slows delivery of oxygen, nutrients and repair cells Hypovascularity matrix remodelling takes considerably longer than in other tissues Low metabolic turnover healing tendon frequently forms disorganised scar tissue with inferior mechanical properties Poor spontaneous repair quality standard management is largely loading modification, physiotherapy and time Limited pharmacological options 2

Assessing alcohol intake & its dose dependent effects on liver enzymes by 24-h recall and questionnaire using NHANES 2001-2010 data