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Both TNF- and IL-1 are associated with reduced sperm count, sperm motility and morphology, as well as increased ROS and higher MDA levels ( Consistently with the findings discussed above, androgenic enzyme data indicate downregulation of testicular 3-HSD and 17-HSD, two key enzymes of steroidogenesis whose impairment is recognized as a marker of testicular failure (Ullah et al., 2018)

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