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Nle-AngIV also increased spine numbers to 32 spines/50m, but to a lesser extent than Dihexa
Thus, both the morphological and mechanical properties of the ECM play crucial roles in regulating asymmetric stem cell division and differentiation, epithelial-mesenchymal transition, cell migration, and neoplastic cell differentiation and proliferation, both in primary and metastatic sites ( 8.1 The atomic force microscopy for studying biomechanical properties The mechanical properties of 3D models, such as PDOs, spheroids or scaffold-based systems, can be precisely adjusted to simulate a wide range of tissue stiffnesses (McKenzie et al., 2018)
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