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If youre thinking about taking a GLP-1 weight loss medication, it can be confusing to realize that that GLP-1s fall into two categories: Tirzepatide (Mounjaro and Zepbound), and semaglutide (Ozempic, Wegovy, and Rybelsus) medications
Bioactive plant compounds, such as curcumin and resveratrol, inhibit DPP-4 activity in vitro and in diabetic animal models, which can prolong the active form of GLP-1 and contribute to improved glycemic control and modest weight effects in preclinical settings
The only published efficacy trial for ipamorelin failed its primary endpoint Beck DE, Sweeney WB, McCarter MD (2014), a multicenter, double-blind, placebo-controlled trial in bowel-resection patients sponsored by Rhythm Pharmaceuticals, tested ipamorelin for postoperative ileus
For the more serious side effects, it could point to the medication itself
P = 0.18
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