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Result Genetically proxied GLP-1RA exposure was associated with a lower risk of schizophrenia (OR = 0.72, 95% CI [0.610.86]), bipolar disorder (OR = 0.91, 95% CI [0.880.94]), bulimia nervosa (OR = 0.34, 95% CI [0.230.52]), post-traumatic stress disorder (PTSD) (OR = 0.45, 95% CI [0.310.67]), and autism (OR = 0.55, 95% CI [0.320.93]), all P 1%) significantly ( p 0.001
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If results indicate inferior PK propertiessuch as high clearance, short half-life (t 1/2 ) and/or low bioavailabilityPD effects will likely be sub-optimal
In the test (in vitro), FAD stimulates Gred, and the increase in enzyme activity is measured
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