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At first, doctors prescribed these drugs to people with type 2 diabetes because these medications were designed to help the pancreas produce insulin. 1 But in the past few years, doctors have begun prescribing them for weight loss after the Food and Drug Administration approved GLP-1s for people with obesity

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Tirzepatide suppresses this compensatory ghrelin increase through central nervous system effects, breaking the typical hunger rebound cycle

The absence of visible problems does not guarantee the peptide is still potent