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Moreover, administration of exendin-4 led to a reduction in 5-HT and 5-HIAA, whereas GLP-1R antagonists increased the levels of serotonin and its metabolites [56]

In this context, GLP-1 therapies are best understood as one component within a broader strategy

These side effects and medical conditions encompass stomach paralysis, gallbladder disease, cyclic vomiting syndrome, and other stomach-related problems

Important strategies include: Dietary adjustments: Eating a balanced diet low in fat and high in fiber

Creatine supplementation may modestly increase serum creatinine levels, which reflects increased creatine metabolism rather than impaired kidney function