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This outcome has been attributed to the low transduction efficiency of AAV1 vectors in human cardiomyocytes, highlighting the need for improved gene delivery strategies

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Rev Neurol (paris) 176:148165

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At the end of 2018, European Medicines Agency (EMA) and the Institute for Drugs and Medical Devices (BfArM) issued a red hand letter that highlighted the connection between increasing doses of hydrochlorothiazide and the development of non-melanoma skin cancer

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