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it is always available

The ideal approach depends on individual circumstances

Doctors should increase doses only after confirming the patient's tolerance without major gastrointestinal effects [10]

Annu Rev Pharmacol Toxicol 43:23360 Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

To increase tolerability, semaglutide doses are typically increased over several months, and effects on weight loss are greatest at the highest doses