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In the 3-KO and WT groups, male mice aged 1214 weeks were divided into three subgroups including: saline control, AOD9604 administered at a dose of 250 g/kg/day, and hGH administered at a dose of 1 mg/kg/day
Adding MOTS-C to an AOD 9604 stack targets mitochondrial function and cellular energy metabolism
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MOTS-c and 5-Amino-1MQ address two separate metabolic constraints AMPK suppression and NAD+ depletion that often coexist in metabolic dysfunction models
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